The US is to end its support for offensive operations by its allies in Yemen, which has been devastated by a six-year war in which more than 110,000 people are believed to have died.
"The war in Yemen must end," President Joe Biden said in his first major foreign policy speech.
Under Mr Biden's two predecessors, the US backed a coalition led by Saudi Arabia against Houthi rebels in Yemen.
The conflict has left millions of Yemenis on the brink of starvation.
Fighting began in 2014 between a weak Yemeni government and the Houthi rebel movement. It escalated a year later, when Saudi Arabia and eight other Arab states - backed by the US, the UK and France - began air strikes against the Houthis.
Mr Biden announced other changes to US foreign policy, such as a significant increase in the number of refugees accepted by the US, and a reversal of the decision to withdraw American troops from Germany, where they have been stationed since the end of World War Two.
His speech marks a sharp break with the policies of former president Donald Trump, who left office last month.
What does the Yemen announcement mean?
The US has been backing the Yemeni government and its Saudi-led allies in their war against the Houthis. As a result of Thursday's announcement, the US will stop supporting offensive operations, including the sale of precision-guided munitions to Saudi Arabia and the United Arab Emirates (UAE).
This will not affect operations against al-Qaeda in the Arabian Peninsula.
The Biden administration had already put a temporary halt on arms sales to Saudi Arabia and the UAE.
Mr Biden is expected to name his new Yemen envoy as Tim Lenderking, an experienced diplomat and Middle East specialist.
This marks a change of tack from Mr Trump's administration, which increased support for the Saudi-led coalition. Last month Mr Trump's Secretary of State, Mike Pompeo, announced that the Houthis were being designated a "terrorist organisation".
He said the aim was to hold the Houthis accountable for cross-border attacks and deter "malign activity" by their backer Iran.
Aid organisations criticised the move, warning that it could prevent them from operating in areas where millions are in urgent need of food aid.
Last week, the Biden administration said it would exempt certain transactions involving the Houthis from sanctions. That exemption will expire on 26 February.
The United Nations says Yemen is the world's worst humanitarian crisis, with 80% of the population in need of aid or protection.
These announcements confirm President Biden's pledge to end Yemen's destructive war. Halting US support to the Saudi-led coalition's offensive operations won't close this bloody chapter, but it sends a strong signal to leaders in Riyadh and Abu Dhabi - they've also been trying to find ways to extricate themselves from this quagmire.
Achieving peace among Yemen's bitter enemies will be a monumental challenge. Tim Lenderking is set to be the first US envoy for Yemen since this war was unleashed nearly six years ago. He's worked on this file for years and is known to everyone who matters.
Western diplomats, as well as Yemenis, have welcomed this new US engagement. In 2015, President Obama gave a green light to the Saudi-led campaign, partly to ease the Kingdom's anger over the Iran nuclear deal. Now new US envoys on Yemen, and Iran, are tasked with ending this war, and the regional rivalries which still fuel it.
What else did Biden say?
The US will raise the cap on refugee admissions from 15,000 to 125,000 for the fiscal year.
The withdrawal of US troops from Germany will be frozen and forces will remain at their current level of about 36,000. Under Mr Trump, the US was going to reduce its presence by 12,000, with about 5,600 to be deployed elsewhere in Europe.
Mr Biden called on Myanmar's military rulers to release civilian leader Aung San Suu Kyi and restore democracy.
He also promised to engage diplomatically with Russia but to be tougher on Moscow than Mr Trump, saying the US would not "roll over".
Latest Stories
-
Alan obviously has an issue with Bawumia overtaking him – Ofosu Nkansah
2 mins -
Record number of Ghanaians studying in the United States; earn $9.2m in scholarships
7 mins -
Empowering entrepreneurs: US government pledges support for women businesses
44 mins -
Security retooling projects strengthen Ghana’s capabilities against threats – Akufo-Addo
48 mins -
Savannah Regional Peace Council sensitises students on violent extremism
52 mins -
NCCE organises dialogue for parliamentary candidates in Ada constituency
53 mins -
Current economic challenges exceed the 1999 – 2000 crisis – Goosie Tanoh
55 mins -
Emancipate yourself from all political slavery – Independent Candidate
56 mins -
Ekumfi people urged to be ambassadors of peace
57 mins -
Kwahumanhene destooled for misconduct – Kwahumanhemaa confirms
1 hour -
Fatal accident in Binduri claims one life, leaves several injured
1 hour -
‘Don’t be trigger-happy’ – Saanie Daara on calls to sack Otto Addo, GFA leadership
1 hour -
EC trains visually-impaired voters in Ahafo on proper use of tactile jacket
1 hour -
Alan to establish ‘Creative Arts Development Fund’ to empower talented creatives
1 hour -
Bono Regional Minister calls for a strengthened local government system
1 hour