Virgin Atlantic has announced it is to cut more than 3,000 jobs in the UK and end its operation at Gatwick airport.
The shock announcement comes after rival British Airways said it could not rule out closing its Gatwick operation. Pilots' union Balpa described it as "devastating".
Many airlines have been struggling as the coronavirus pandemic has brought global travel to a virtual standstill.
The airline currently employs a total of about 10,000 people.
Virgin Atlantic, which is in the process of applying for emergency loans from the government, said that jobs will be lost across the board.
"We have weathered many storms since our first flight 36 years ago but none has been as devastating as Covid-19 and the associated loss of life and livelihood for so many," said Virgin Atlantic chief executive Shai Weiss.
'Dire situation'
Balpa the union said: "This is another terrible blow for the industry and is evidence of the dire situation facing UK aviation.
Balpa general secretary, Brian Strutton, said: "Our members and all staff in Virgin Atlantic will be shocked by the scale of this bombshell. We will be challenging Virgin very hard to justify this."
Virgin Atlantic also said it will move its flying programme from Gatwick to Heathrow. It said it intended to keep its slots at Gatwick "so it can return in line with customer demand".
It was 28% at British Airways. Now 30% of jobs will be lost at Virgin Atlantic.
The UK's aviation sector is shrinking in size. No airline or airport is immune.
Virgin Atlantic was Gatwick's ninth-largest airline, so it's a blow, but not a knock-out punch.
However, British Airways, which is Gatwick's second-biggest customer, has indicated that it also might not restart its Gatwick operation.
If BA does pull out, it would carry deeper ramifications.
Just a few weeks ago, several UK airports had elaborate, expensive and very controversial expansion plans in the pipeline. The big ones were operating at or very near capacity.
But the whole aviation sector is living a new reality.
When lockdown restrictions ease and flight schedules are increased again, there will be fewer passengers, fewer and probably more expensive flights and sadly thousands of cabin crew, pilots and ground staff will have lost their jobs.
And the consensus is that it will take years for the aviation sector to bounce back to where it was before the pandemic.
Commenting on its own future, Gatwick said: "We remain very optimistic about the long-term prospects of Gatwick Airport and our resilience as a business, and having remained open throughout this pandemic we are in a strong position to extend our current operations quickly to meet demand."
Other airlines have already announced that they intend to cut jobs because of the collapse in demand for travel due to the coronavirus pandemic.
Last week, British Airways said it was set to cut up to 12,000 jobs from its 42,000-strong workforce. It also told staff that its Gatwick airport operation might not reopen after the pandemic passes.
Ryanair has also said it will cut 3,000 jobs - 15% of its workforce - with boss Michael O'Leary saying the move was "the minimum that we need just to survive the next 12 months".
Virgin Atlantic said it had begun a 45-day consultation period on the job losses with unions Balpa and Unite.
Virgin Atlantic also plans to reduce the size of its fleet of aircraft from 45 to 35 by the summer of 2022.
It hopes to restore about 60% of its pre-pandemic flying capacity by the end of 2020.
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