Real are looking to reach the last eight of the competition for the sixth season in a row, and have a healthy lead after Cristiano Ronaldo and Jese scored in the first leg in the Italian capital.
Roma meanwhile have a task on their hands if they are to reach the quarter-finals for the first time since 2008, but go into the game on the back of a fine 4-1 win over Fiorentina on Friday night.
#JoySports will provide live Twitter coverage of this game from 7.30pm on Tuesday evening. Follow our account: @JoySportsGH.
Match stats:
No team has scored more goals than Real Madrid in the Champions League this season (21, alongside Bayern Munich).
Real Madrid have reached the knockout stages of the Champions League for the 19th consecutive season - the longest run in the history of the competition. They've reached the semi-finals in each of the last five seasons.
Roma are in the knockout stages of the Champions League for the first time since 2010/11. They were eliminated by Shakhtar Donetsk in the Last 16.
Real Madrid are one of two clubs still unbeaten in the Champions League this season, the other being Barcelona.
VIDEO PREVIEW:
European football expert Paolo Bandini predicts Real Madrid will advance to their sixth straight quarterfinal tonight. He also touches on the day's other game, where Wolfsburg host Gent with the Germans leading 3-2 on aggregate.
Bandini, who works for ESPN, BT Sport, The Guardian and others, speaks on all this week's Champions League games with Joy Sports Gary Al-Smith on the Joy News channel. Click here to watch
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