Egypt rallied to beat Congo 2-1 at the Stade Municipal de Kintele in Brazzaville to take the lead in Group E.
Earlier on Friday, Ghana drew 0-0 with Uganda at the Tamale Sports Stadium.
It was Congo who broke the deadlock six minutes before the half-hour mark through Ferebory Dore who headed home for the opener to beat legendary goalkeeper Essam El-Hadary.
But the lead only lasted for seventeen minutes as Mohamed Salah made it 1-1 for Egypt after heading home a superb Mohamed Abdel-Shafy cross.
The Pharaohs took the lead in the 73rd minute through Abdallah Saied who was set-up by Salah.
Saied nearly made it 3-1 to the Pharaohs in stoppage time, but Congo goalkeeper Gildas Kiwoko came off his goalline to deny the attacker.
Egypt will host Ghana next month and a win will all but confirm their status as firm favourites to qualify for a first World Cup finals since 1990.
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