Serie A leaders Napoli are out of the Coppa Italia after a last-16 penalty shootout defeat by Cremonese.
The visitors, bottom of Italy's top flight, took the lead through Charles Pickel.
First-half goals from Juan Jesus and Giovanni Simeone turned the game on its head, but Felix Afena-Gyan levelled late on.
Cremonese's Leonardo Sernicola was sent off in extra time, but the visitors prevailed 5-4 in the shootout.
Stanislav Lobotka missed Napoli's fourth spot-kick, while Cremonese scored all five of theirs to stun the 2019-20 winners.
Luciano Spalletti's side are nine points clear at the top of Serie A, having thumped third-placed Juventus 5-1 on Friday.
Cremonese are without a win in Serie A this season, leaving them stranded at the foot of the table and nine points adrift of safety.
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