Liz Truss has said she was never given a "realistic chance" to implement her radical tax-cutting agenda by her party.
In a 4,000-word essay in the Sunday Telegraph, Ms Truss stood by her plans to boost economic growth, arguing they were brought down by "the left-wing economic establishment".
They are the first public comments the ex-PM has made on her resignation.
But she said she was not "blameless" for the unravelling of the mini-budget.
Business Secretary Grant Shapps, who was appointed by Ms Truss as her home secretary during her final week in office, said she "clearly" had not had the right approach to taxation.
Speaking on BBC One's Sunday With Laura Kuenssberg show, he said her desire for lower taxes in the long term was correct, but inflation should have been lowered first.
Ms Truss was forced to quit after she and her chancellor Kwasi Kwarteng's £45bn package of tax cuts panicked the markets and tanked the pound to a record low.
Her brief time in power - 49 days - made her the shortest-serving prime minister in UK history.
Ms Truss said that while her experience last autumn was "bruising for me personally", she believed that over the medium term her policies would have increased growth and therefore brought down debt.
She argued that the government was made a "scapegoat" for developments that had been brewing for some time.
"Frankly, we were also pushing water uphill. Large parts of the media and the wider public sphere had become unfamiliar with key arguments about tax and economic policy and over time sentiment had shifted leftward," she wrote.
"Regrettably, the government became a useful scapegoat for problems that had been brewing over a number of months."
She also said she had not appreciated the strength of the resistance she would face to her plans - including plans to abolish the 45p top rate of income tax.
"I assumed upon entering Downing Street that my mandate would be respected and accepted. How wrong I was. While I anticipated resistance to my programme from the system, I underestimated the extent of it," she writes.
Mr Kwarteng dropped the 45p income tax proposals 10 days after they were announced, telling the BBC it was "a massive distraction on what was a strong package".
Less than a fortnight later, Ms Truss sacked Mr Kwarteng, something she said she was "deeply disturbed by".
"Kwasi Kwarteng had put together a brave package that was genuinely transformative - he is an original thinker and a great advocate for Conservative ideas. But at this point, it was clear that the policy agenda could not survive and my priority had to be avoiding a serious meltdown for the UK," she wrote.
With the benefit of hindsight, she writes that she would have acted differently during her premiership - but she still backs her plans for growth.
"I have lost track of how many people have written to me or approached me since leaving Downing Street to say that they believe my diagnosis of the problems causing our country's economic lethargy was correct and that they shared my enthusiasm for the solutions I was proposing," she said.
After 100 days of "soul searching" we have a version of events from the shortest-serving UK Prime Minister in history.
This is Liz Truss's catastrophic time in office, described and defended in her own words.
At some length, she attempts to argue her case and answer for her actions. There is reflection and regret but not the apology which many might expect.
What burns through this 4000-word essay is a sense from Liz Truss that almost everything was against her as she makes a case for what might have been.
The system, officials, Conservative MPs all played a part, she argues, in stopping her from achieving her aim of economic growth through tax cuts and deregulation.
There are breathtaking reminders of how high the stakes were as her policies sent shockwaves through the economy - Kwasi Kwarteng had to go to avoid "a serious meltdown for the UK" and "the starkest of warnings" came from officials that the country may have to default on its debt.
Despite her downfall, Liz Truss argues many still share her enthusiasm for what she was trying to achieve.
Sir Jake Berry, who was Conservative party chairman under Ms Truss, said he agreed with her "diagnosis" of the problems facing the UK economy, but "not necessarily the cure".
Speaking to Laura Kuenssberg, he added that Ms Truss had been "wrong" to say the Conservatives had failed to make the argument for lower taxes.
Meanwhile, shadow chancellor Rachel Reeves said Ms Truss's policies "made working people pay the price".
"The Conservatives crashed the economy, sank the pound, put pensions in peril and made working people pay the price through higher mortgages for years to come.
"After 13 years of low growth, squeezed wages and higher taxes under the Tories, only Labour offers the leadership and ideas to fix our economy and to get it growing."
While Liz Truss resigned as prime minister, she is still serving in parliament as the MP for South West Norfolk.
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