No upsets on the day as the big four won on Tuesday.
And if the draw goes to plan Nadal will have to get past Andy Murray and Roger Federer to earn a shot at a third title, potentially against top seed Novak Djokovic in the final.
Nadal, who has slipped down the sport's pecking order after 18 months of injury and below-par performances, showed glimpses of his power and determination with a win against Thomaz Bellucci.
An abdomen injury that scuppered Jo-Wilfried Tsonga's Wimbledon warm-up plans did not stop a win.
Roger Federer began his quest for an eighth Wimbledon title in fine style as he cruised through his opening match against Damit Dzumhur.
Andy Murray won his first-round match at Wimbledon, beating Mikhail Kukushkin 6-4 7-6 6-4.
Men's results - highlights
(Numbers preceding player's name is their ranking, if any)
3-Andy Murray (Britain) beat Mikhail Kukushkin (Kazakhstan) 6-4 7-6(3) 6-4
10-Rafa Nadal (Spain) beat Thomaz Bellucci (Brazil) 6-4 6-2 6-4
12-Gilles Simon (France) beat Nicolas Almagro (Spain) 6-4 6-4 7-5
13-Jo-Wilfried Tsonga (France) beat Gilles Muller (Luxembourg) 7-6(8) 6-7(3) 6-4 3-6 6-2
18-Gael Monfils (France) beat Pablo Carreno (Spain) 6-4 6-4 7-5
2-Roger Federer (Switzerland) beat Damir Dzumhur (Bosnia and Herzegovina) 6-1 6-3 6-3
22-Viktor Troicki (Serbia) beat Aleksandr Nedovyesov (Kazakhstan) 6-1 6-4 3-6 6-3
25-Andreas Seppi (Italy) beat Brydan Klein (Britain) 6-3 6-2 6-2
Pablo Andujar (Spain) beat 29-Guillermo Garcia-Lopez (Spain) 3-6 6-4 3-6 7-5 6-4
Robin Haase (Netherlands) beat Alejandro Falla (Colombia) 6-2 3-6 6-4 6-2
Lukas Rosol (Czech Republic) beat Ernests Gulbis (Latvia) 7-6(2) 6-3 7-6(4)
Albert Ramos (Spain) beat Denis Istomin (Uzbekistan) 6-2 6-2 3-2 (Istomin retired)
Alexandr Dolgopolov (Ukraine) beat Kyle Edmund (Britain) 7-6(4) 6-1 6-2
Women's results - highlights
(Numbers preceding player's name is their ranking, if any)
Defending champion Petra Kvitova (below, pictured) was in ominous form as she destroyed Kiki Bertens in her opening match at Wimbledon.
The Czech star lost just a single point on her serve throughout the match - and that was a double fault in the final game, as she wrapped up a 6-1 6-0 victory in less just 35 minutes.
Heather Watson saved three match points as she beat Caroline Garcia 1-6 6-3 8-6 to move into the second round.
Eugenie Bouchard's fall from grace continued with a first-round defeat by China's Duan Yingying as her hopes of repeating last year's run to the final evaporated.
Since reaching the quarter-finals of the Australian Open in January she has suffered eight first-round defeats.
Highlights
2-Petra Kvitova (Czech Republic) beat Kiki Bertens (Netherlands) 6-1 6-0
5-Caroline Wozniacki (Denmark) beat Zheng Saisai (China) 7-5 6-0
8-Ekaterina Makarova (Russia) beat Sachia Vickery (U.S.) 6-2 6-4
10-Angelique Kerber (Germany) beat Carina Witthoeft (Germany) 6-0 6-0
Duan Yingying (China) beat 12-Eugenie Bouchard (Canada) 7-6(3) 6-4
13-Agnieszka Radwanska (Poland) beat Lucie Hradecka (Czech Republic) 6-3 6-2
20-Garbine Muguruza Blanco (Spain) beat Varvara Lepchenko (U.S.) 6-4 6-1
25-Alize Cornet (France) beat Ana Konjuh (Croatia) 6-2 6-2
26-Svetlana Kuznetsova (Russia) beat Laura Siegemund (Germany) 6-3 6-4
28-Jelena Jankovic (Serbia) beat Elena Vesnina (Russia) 6-4 3-6 10-8
Heather Watson (Britain) beat 32-Caroline Garcia (France) 1-6 6-3 8-6
Jana Cepelova (Slovakia) beat 3-Simona Halep (Romania) 5-7 6-4 6-3
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