The latest case is the mother of a 15-year-old boy who was diagnosed in September.
Health officials are now closely monitoring both patients to prevent further spread.
Deputy Director of Disease Surveillance at the Ghana Health Service, Dr. Dennis Laryea, assured the public that authorities are taking all necessary steps to contain the virus.
Mpox, also known as Monkeypox, is a viral infection transmitted through direct contact with an infected person or contaminated surfaces.
Common symptoms include fever, rash, and swollen lymph nodes.
Health officials urge the public to remain vigilant, follow hygiene protocols, and promptly report any suspected symptoms to healthcare providers.
The Ghana Health Service has intensified public awareness efforts and is working with local health facilities to ensure preparedness for potential cases.
Additional resources have been mobilised to track other contacts, especially in affected communities.
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