Chelsea lost their fifth successive game since the return of Frank Lampard as Brentford won at Stamford Bridge to strengthen their position in the Premier League's top 10.
The visitors did not have a shot on target in the first half but took the lead midway through when Mathias Jorgensen's flick from a corner hit Cesar Azpilicueta on his shoulder to deflect into the back of the net.
Chelsea once again struggled to create chances and a hugely disappointing first half ended with boos from some of the home supporters.
The Blues did improve after the break, thanks largely to the introduction of striker Pierre-Emerick Aubameyang, who mis-hit an overhead kick from a dangerous position before firing a low strike at Brentford goalkeeper David Raya.
But they failed to find an equaliser and Brentford wrapped up a hugely impressive win late on when Bryan Mbeumo cut into the box before smashing a shot into the back of the net.
The defeat leaves Chelsea in the bottom half of the table as they sit 11th, six points behind Fulham in 10th and eight behind Brentford, who move up to ninth.
Miserable campaign can't end soon enough for Chelsea
This is a season that Chelsea fans will just want to come to an end, with the return of club legend Lampard having failed to steady the ship.
Every game since the 44-year-old's appointment on 3 April has ended in defeat - three in the Premier League and two in the Champions League - while the Blues have scored just once so far under Lampard's watch as their season-long struggle in front of goal continued.
Chelsea fans' hopes of seeing that dismal run ended on Wednesday would not have been lifted by the team news, as Lampard selected what appeared to be a pretty conservative side to try and halt the run of losses, with Joao Felix and Mykhailo Mudryk on the bench and Raheem Sterling leading the attack.
Consequently, they offered almost no attacking threat in the first half, with Thiago Silva's tame header the best of their few opportunities.
The introduction of Mudryk and Aubameyang at the start of the second half saw a brief improvement in Chelsea's attacking threat, with the latter providing the Blues with more of a focal point up front.
But they failed to capitalise on that as Brentford punished them with the sort of clinical finishing they crave when Mbeumo scored Brentford's second with their first shot on target.
Bees flying high
In contrast to Chelsea, this has been a season to enjoy for Brentford fans - they've never been in danger of relegation and have even enjoyed a flirtation with the European places.
A run of six Premier League games without a win prior to this game may have ended hopes of a top-seven finish, as they sit six points behind Tottenham in seventh having played a game more.
Brentford claimed a memorable 4-1 victory at Stamford Bridge last season and while a repeat of such a win never looked likely they were nevertheless impressively comfortable against the struggling Blues.
Thomas Frank's side finished 13th in their first Premier League campaign last season and, with five games remaining, they are firmly on target to comfortably better that this term.
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