Sepp Blatter says Fifa is looking carefully at the decision to allow Egypt to play their World Cup tie against Ghana in Cairo.
Ghana's request to have the match on 19 November moved to a neutral venue on security grounds has been rejected.
This prompted the country's Sports Minister to request an urgent meeting with Fifa to discuss the issue.
There has been political and social unrest in Egypt since President Mohamed Morsi was overthrown by the military.
In his first public comments on the matter, Blatter said: "We should be very careful because they (Ghana) fear something should (might) happen."
"We are looking at this matter, there have been matches played in Egypt, international club matches, but we must be careful."
The Fifa president Sepp Blatter also revealed that he wants to get rid of World Cup qualifying play-off ties in future.
The head of the game's world governing body says play-offs are a hard way for teams to miss out on the finals.
Twenty teams, plus hosts Brazil, have qualified for next year's tournament via round-robin groups.
The remaining 11 places will be decided this month, all in two-legged play-offs.
Five matches will be played in Africa, between runners-up from the 10 second-round groups.
Four ties will be played in Europe, involving the best eight runners-up from nine groups, plus two intercontinental featuring Jordan against Uruguay and Mexico v New Zealand.
"It will be drama because you have to eliminate teams now in two matches," Blatter said in a video interview on Fifa's website.
"I think this is good for television, this is good for the spectacle of football but I think we should try to find a solution where at the end of the qualification, you are in or out, and not this play-off.
"This play-off.... it gives more intensive action, but for those teams (who are knocked out) it is a hard way to go."
Latest Stories
-
We need quality products locally; importing to run top hotels increases cost – Labadi Beach Hotel MD
4 hours -
2024/25 GPL: Basake Holy Stars face tough test against Medeama at CAM Park
4 hours -
Kwahu-Nkwatia development chief advocates for peaceful elections
4 hours -
We must declare state of emergency over galamsey, halt all mining – VLK Djokoto
5 hours -
JL Plantations, WES Trade sign MoU to promote commercial agriculture in Ghana
5 hours -
APSU to host biggest ‘Aponkye K’ event on September 28
5 hours -
Meet the 1st Ghanaian House Manager of Labadi Beach Hotel, now the MD David Eduaful
5 hours -
Ghana’s farming and construction methods destroying the environment – Environmental Expert
6 hours -
GPL 2024/25: Young Apostles, Aduana chase first win in Wechi clash
6 hours -
GPL 24/25: Hearts of Lions seek to inflict first defeat on leaders Gold Stars
7 hours -
GPL 2024/25: Hungry Accra Lions eyefirst win against Nsoatreman FC
7 hours -
CHRI condemns police conduct during Democracy Hub protests, calls for action
7 hours -
Women’s Premier Super Cup: Ampem Darkoa join Dreamz Ladies in final after win over Faith Ladies
7 hours -
Expert discusses causes, effects, and solutions for erectile dysfunction
8 hours -
Gas tanker overturns at Darkuman near Cable and Wireless
8 hours