JoyNews sources say that Minister for Food and Agriculture, Dr Owusu Afriyie Akoto may tender his resignation today.
This comes four days after Trade Minister, Alan John Kwadwo Kyerematen, resigned from the government.
It is not clear yet the rationale behind Dr Akoto's expected move.
Presidential Affairs correspondent, Elton Brobbey, says the Minister is expected to meet President Akufo-Addo later this afternoon to formally communicate his intention.
"We are told that there has been verbal communication regarding this matter so it is not a surprise to President Akufo-Addo. But what we are picking up is that at 2 pm when he meets the President, he will formally announce his resignation," he said on Tuesday.
Dr Afriyie Akoto has been tipped as one of the personalities eyeing the flagbrearership position of the governing New Patriotic Party (NPP) ahead of the 2024 elections.
Critics say this may be a tactic to allow him to concentrate on the leadership ambition of his party.
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