Russian Karen Khachanov will contest his first Australian Open semi-final after Sebastian Korda was forced to retire with a wrist injury.
Korda was growing into the match when he began to struggle with his right wrist, taking a medical timeout midway through the second set.
The American lost seven straight games on his return before retiring with the score at 7-6 (7-5) 6-3 3-0.
"Obviously it's not the way you want to finish the match," Khachanov said.
"Until a certain point it was very competitive," he added. "Sebastian beat one of my friends, Daniil [Medvedev] in three sets and [Hubert] Hurkacz in five. He's playing great tennis."
After losing the first three games of the third set a visibly disappointed Korda sat down briefly at the change of ends before walking over to shake Khachanov's hand.
Korda, the son of 1998 champion Petr, then left the stadium to a standing ovation.
Khachanov will play either third seed Stefanos Tsitsipas or rising Czech star Jiri Lehecka for a place in Sunday's showpiece.
Olympic silver medallist Khachanov is only the 10th active male player to reach the last eight at all four majors and also reached the semi-finals of last year's US Open
Khachanov started strongly but failed to serve out the opener at 5-3 before taking his third set point of the eventual tie-break with a clinical backhand winner.
After a slow start Korda had grown more competitive but he faded badly after receiving treatment five games in to the second set.
The swift loss of the set followed - although Korda did create two break points as Khachanov briefly tightened up when serving for a 5-3 lead - but the decision was made for the American when he was only able to take a single point from the first three games of the third.
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