Only victory will guarantee Manchester United's passage to the last 16 of the Champions League, but they have major injury worries ahead of Tuesday's trip to wounded Wolfsburg.
United dropped to fourth in the Premier League on Saturday after recording their sixth stalemate of the season at home to West Ham.
And boss Louis van Gaal is all too aware that their killer instinct must return by the time they take to the field in Germany, otherwise they are likely to exit Europe's elite competition at the group stage for only the fourth time in their history.
The Dutchman was expected to lead his team through their group untroubled but after drawing 0-0 at home to PSV Eindhoven last month, there is a real danger they could drop into the Europa League.
Wolfsburg coach Dieter Hecking will be out to repair damaged pride against United after their 29-game unbeaten home run came to an end against Borussia Dortmund at the weekend.
A draw against Van Gaal's side will be enough for Wolfsburg to progress beyond the group stage for the first time, and a win would secure first place in Group B.
Rafa Benitez will rest Gareth Bale and Luka Modric when Malmo visit the Bernabeu on Tuesday evening with Real Madrid's Champions League progress already assured.
Third in La Liga, Benitez's side will be seeking a convincing performance to appease fans left disgruntled by the recent 4-0 mauling at the hands of Barcelona and the club's disqualification from the Copa del Rey for fielding an ineligible player.
However, they have at least strung together four consecutive victories since their humiliation against Barca and Saturday's 4-1 win over Getafe saw Bale, Karim Benzema and Cristiano Ronaldo all score in the same game for the first time this season.
Real face a tough visit to Villarreal on Sunday, and having sealed their place in the last 16 as Group A winners ahead of Paris Saint-Germain, Benitez will rest a number of his star names.Malmo, meanwhile, need to better Shakhtar Donetsk's result in the other game if they are to snatch third spot and a Europa League berth.
With the Swedish domestic season now finished, Age Hareide's side have only played once in the last month, when they went down 5-0 at home to Paris Saint-Germain.
Hareide will be taking charge of the club for the last time in the Champions League after announcing his decision to step down at the end of the year.
Manchester City host a revitalised Borussia Monchengladbach needing a win and a favour from Sevilla to top their Champions League group - from which they have already qualified - to give them a much-needed easier last-16 draw.
Manuel Pellegrini's surrendered top spot in the Premier League to Leicester after they were out-played in every department in a 2-0 defeat at a windswept Britannia Stadium against Stoke on Saturday.
And Gladbach arrive in buoyant mood having brought an end to Bayern Munich's unbeaten record this season thanks to an emphatic 3-1 win.
City's defence have recorded just two clean sheets in the last 18 matches, after not conceding a goal in their opening five games of the season, and it is no coincidence the absence of captain Vincent Kompany to injury has affected their stability at the back.
However, in Europe, they have already booked their spot in the knockout stages, although their hopes of topping Group D rest on Sevilla needing to beat Juventus at home as well as a win of their own at the Etihad Stadium on Tuesday night.
Gladbach can go into the Europa League if they match or better Sevilla's result against Juventus and have risen from bottom of the table to third under new coach Andre Schubert, with his only defeat coming against City in the reverse fixture in late September.
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