Istanbul colleagues said Ebru Timtik has died, 238 days into her hunger strike in Silviri jail demanding a fair trial.
As mourners approached a northern city cemetery during her burial, police fired volleys of teargas.
EU foreign affairs spokesman Peter Stano said Timtik's "tragic" death again showed it was urgent that Turkey "credibly address" its human rights situation and the "serious shortcomings in the Turkish judiciary."
Friends said Ebru Timtik weighed only 30 kilograms (65 pounds) on death in hospital where she and her colleague Aytac Unsal had been transferred in July after going on hunger strike in Istanbul's Silivri prison.
International and local groups, including the Contemporary Lawyers' Association (CHD), had been calling for their release and had questioned the impartiality of courts under President Recep Tayyip Erdogan's rule.
Violent clashes
As Timtik supporters approached a northern Istanbul cemetery chanting "Ebru Timtik is immortal" and the "murderous state will be held to account," helmeted police with shields fired volleys of teargas, reported AFP.
Earlier, as a police helicopter hovered overhead, police backed by armored vehicles, had clashed with Timtik supporters. Police tried to prevent a crowd gathering outside the Istanbul Bar Association, reported the newspaper Evrensel.
At least one lawyer was detained in that incident, the paper said.
Timtik's death, of which news emerged Thursday night, follows similar deaths of two left-wing folk musicians in April and May.
Among 18 lawyers jailed
Last October, a Turkish appeals court had upheld lengthy jail terms imposed on 18 lawyers, Timtik included, facing multiple charges over alleged links to an outlawed Marxist organisation.
In the past, the Revolutionary People's Liberation Party-Front (DHKP-C) had claimed responsibility for attacks, including a 2013 bombing aimed at the US embassy in Ankara in which a Turkish security guard was killed.
Initially detained in September 2018, Timtik was sentenced to 13 and six months jail. Unsal was sentenced to more than 10 years.
Lawyers' groups had cited flaws at her trial, including the removal of judges who had initially ordered releases from pre-trial detention.
In February, Timtik and Unsal began hunger strikes inside Silivri. A forensic report at the time said the pair was consuming only liquids and vitamins.
Reacting to her death, People's Democratic Party (HDP) lawmaker Garo Paylan said in a tweet on Friday that Timtik had been "massacred by the tyrants in power."
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