Ivory Coast's PM Amadou Gon Coulibaly has died after falling ill at a ministerial meeting.
The 61-year-old had been chosen as the ruling party's candidate for October's presidential election, after Alassane Ouattara said he would not seek a third term in office.
Mr Gon Coulibaly had only just returned from France where he had received two-months' heart treatment.
President Ouattara said the country was in mourning.
He said Mr Gon Coulibaly had become unwell during a weekly cabinet meeting and was taken to hospital where he later died.
His death creates huge uncertainty over the election.
Mr Gon Coulibaly had received a heart transplant in 2012 and had travelled to Paris on 2 May for the insertion of a stent.
He returned last Thursday saying: "I am back to take my place by the side of the president, to continue the task of developing and building our country."
Mr Gon Coulibaly was among the favourites to win the presidential election.
An article in Le Monde on Monday quoted one foreign observer as saying: "If Gon Coulibaly were unfit, Ouattara would have no choice but to run as a candidate because there is no plan B.
"This matter has so far remained taboo because the president has clearly shown his willingness to leave and indicated who his choice was to succeed him."
Mr Ouattara's decision in March not to run stunned the country.
At the time, the BBC's James Copnall from the main city, Abidjan, wrote that there was praise from politicians as Mr Ouattara broke the normal mould for the region of trying to remain in power.
Even then it was clear that Mr Gon Coulibaly would be backed as the successor candidate.
Mr Ouattara's supporters say he has brought economic growth, stability and a renewed standing for Ivory Coast on the international stage.
But opposition politicians - and many Ivorians - say that the president has not done enough to bring the nation together, and heal the wounds of the bitter conflict that divided Ivory Coast and then brought him to power.
Around 3,000 people are thought to have died in the war sparked by candidate Laurent Gbagbo's refusal to accept he had lost the 2010 elections to Mr Ouattara, before troops loyal to the current president arrested Mr Gbagbo in April 2011.
The long-running political disputes between him, Mr Ouattara and another former president, Henri Konan Bédié, have been disastrous for Ivory Coast.
Latest Stories
-
IPR Ghana congratulates citizens for peaceful election, calls for unity
5 minutes -
Bawumia’s 8 minutes elite ball that zapped the energy of trigger happy politicians
54 minutes -
It will be a betrayal if National Cathedral saga does not feature in ORAL’s work – Ablakwa
1 hour -
‘It’s unfortunate we had to protect the public purse from Akufo-Addo’ – Ablakwa on ORAL Team’s mission
2 hours -
Congo lawyers say Apple’s supply chain statement must be verified
2 hours -
Stampede in southwestern Nigerian city causes multiple deaths
3 hours -
Tens of thousands without water in Mayotte as curfew brought in
3 hours -
ORAL: We won’t witch-hunt, we’ll focus on transparency, not revenge – Ablakwa
3 hours -
Attempted robbery: Accused claims he carried cutlass for protection
3 hours -
Excavator operator jailed for stealing
4 hours -
African fans age-shame me for putting on some outfits – Tiwa Savage
4 hours -
Tiwa Savage criticised by female fans for stance on cheating in relationships
4 hours -
Bank of England expected to hold interest rates
4 hours -
Congo river boat sinks killing at least 22
5 hours -
Nigeria approves Shell’s $2.4 billion asset sale to Renaissance
5 hours