Hull City's injury problems have been exacerbated after it was confirmed that James Chester needs an operation.
The Wales cap, 25, came off in Sunday's 3-0 loss at West Ham after dislocating a shoulder in an aerial challenge with compatriot James Collins.
A second defender, Alex Bruce, 30, was substituted with a thigh injury.
Manager Steve Bruce said his son is "touch and go" for Newcastle's visit on 31 January - a game that eight other Hull players could also miss.
As well as Chester, Abel Hernandez, Nikica Jelavic, Liam Rosenior, Andy Robertson, Mohamed Diame, Gaston Ramirez and Robert Snodgrass are all unlikely to be fit.
Chester's injury could also make him a doubt for Wales' 2015 European qualifier against Israel in March.
"It's all hands to the pump," said manager Bruce, who confirmed he is seeking one new signing before the transfer window closes.
Defeat at Upton Park was Hull's third in a row and their sixth in eight matches.
After an opening half in which Sone Aluko and Ahmed Elmohamady missed fine chances, the visitors collapsed after the interval.
Andy Carroll, Morgan Amalfitano and Stewart Downing each scored as Hull opted to use defender Harry Maguire in attack alongside winger Aluko.
"We've got seven or eight big players missing and in the second half it did show," Bruce said.
"We gifted West Ham their opportunities. It's become a recurring them but we can't keep bleating on about it, we've got to roll up our sleeves."
Latest Stories
-
I am not ready to sign any artiste to my record label – Kuami Eugene
26 mins -
Gov’t spokesperson on governance & security calls for probe into ballot paper errors
29 mins -
Free dialysis treatment to be available in 40 facilities from December 1 – NHIA CEO
43 mins -
NHIA will need GHC57 million annually to fund free dialysis treatment – NHIA CEO
49 mins -
MELPWU signs first-ever Collective Agreement with government
1 hour -
I’ve not been evicted from my home – Tema Central MP refutes ‘unfounded’ reports
1 hour -
After Free SHS, what next? – Alan quizzes and pledges review to empower graduates
2 hours -
Wontumi FM’s Oheneba Asiedu granted bail
2 hours -
Alan promises to amend the Constitution to limit presidential powers
2 hours -
Ghana to face liquidity pressures in 2025, 2026 despite restructuring most of its debt – Fitch
2 hours -
NPP’s record of delivering on promises is unmatched – Bawumia
2 hours -
Mahama: It’s time to dismiss the incompetent NPP government
2 hours -
‘It’s extremely embarrassing’ – Ernest Thompson on Ghana’s AFCON failure
3 hours -
Today’s front pages: Monday, November 25, 2024
3 hours -
T-bill auction: Government misses target again; interest rates continue to rise
3 hours